Manchester United will host Scottish side Rangers and travel to Turkey to face Jose Mourinho's Fenerbahce in the new 36-team Europa League after the draw was made on Friday.
Two Premier Leagues teams have made it to the competition this year, Tottenham Hotspur after finishing fifth and United through their FA Cup victory.
The tournament's league phase has four pots with nine clubs each, divided according to club coefficient. Clubs will face eight different teams with four games at home and four away, picked with the help of a computer.
The fixtures are determined by seeding and every result will factor into the comprehensive league standings.
Mourinho, who steered Manchester United to a Europa League triumph in 2017 with a 2-0 final victory over Ajax, is poised for a reunion with his former club, where he served as the manager from 2016 to 2018.
Tottenham, winners of the tournament's inaugural edition in 1972, return to European competition following a year-long hiatus. Ange Postecoglou's side take on Serie A side AS Roma and will travel to Scotland to face Rangers, among six other planned fixtures.
The Europa League final will take place in Bilbao, Spain, on May 21 2025.