Harry Kane’s hopes of winning a trophy this season were dented, as his side lost the first leg of their Champions League round of 16 tie against Lazio 1-0.
Ciro Immobile scored a 69th-minute penalty to earn hosts Lazio a narrow victory over 10-man Bayern Munich in the Champions League.
Immobile converted his spot-kick after Bayern defender Dayot Upamecano's clumsy challenge on Gustav Isaksen for which the France international was sent off with a straight red card.
Disciplined Lazio stifled the German side's attacks and Bayern were toothless throughout, failing to get a single effort on target in the match.
The Bavarians, favourites going into the game, were desperate to bounce back from Saturday's 3-0 Bundesliga loss to leaders Bayer Leverkusen which left them five points off the top.
They will return to Munich with more pressure piling on coach Thomas Tuchel and his team after their second straight defeat. They have failed to score in their last two games.
"We started well had a chance in the first minute and then with Harry Kane and then with Jamal Musiala. We had the game under control in the first half," Tuchel said.
"But in the second our performance dropped inexplicably. We made too many individual errors and made our opponents stronger and we lost concentration. We lost our rhythm.
"It was completely our responsibility. We lost a game today that in the first half looked like we could not lose it."
Tuchel played down concerns about his situation. "Worried about my future? No I am not," he said.