England beat Ireland and France by 12 and 36 points respectively in their first two matches of the campaign.
They are currently ranked third in the world.
Play from the Millennium Stadium in Cardiff gets underway at 8:45 PM UAE time.
Meanwhile Scotland travel to France for their latest Six Nations fixture.
Action from the Stade de France starts at 6:15 PM UAE time.
Palace's Mateta denies Arsenal win to leave Liverpool on brink of title
Arsenal kept Liverpool's Premier League title-winning champagne on ice, but only just, as they were twice pegged back at home by Crystal Palace with Jean-Philippe Mateta scoring a superb equaliser in a 2-2 draw on Wednesday.
Tennis great Agassi to make pro pickleball debut
Former tennis world number one Andre Agassi will make his professional debut in the fast-growing sport of pickelball next week when he teams up with top ranked Anna Leigh Waters for the mixed doubles at the US Open Pickleball Championships.
Guardiola calls season 'bad' even with Champions League within reach
Manchester City manager Pep Guardiola scoffed at suggestions that his team could look back on this season as a special one if they clinch a Champions League berth.
Olmo strikes to keep Barca's title charge on track
Barcelona's Dani Olmo scored inside the first minute of the second half to earn a hard-fought 1-0 home win against Mallorca on Tuesday, extending their lead over Real Madrid at the top of the table to seven points with five games to go.
India's Bumrah, Mandhana win top Wisden awards
India duo Jasprit Bumrah and Smriti Mandhana have been crowned the world's leading cricketers in the latest edition of the Wisden Cricketers' Almanack.
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