Arsenal and Chelsea made it through to the Europa League last-eight while Inter and Sevilla were knocked out.
Arsenal are into the quarter-finals of the Europa League after beating Rennes 3-0 at the Emirates Stadium.
Pierre-Emerick Aubameyang scored twice and set-up Ainsley Maitland-Niles as the Gunners overturned a two-goal deficit from the first leg, progressing 4-3 overall.
They're joined in the last-eight by London rivals Chelsea, who thrashed Dynamo Kiev 5-0 away from home to complete an 8-0 aggregate victory.
Olivier Giroud claimed a hat-trick, with Marcus Alonso and Callum Hudson-Odoi also getting on the scoresheet.
Italian giants Internazionale were knocked out by Eintracht Frankfurt as Luka Jovic got the only goal of the tie for the German outfit at the San Siro.
That wasn't the only shock result however, as Spanish side Sevilla, who have won the competition a record five times, lost 4-3 to Slavia Prague after extra-time to go out 6-5 on aggregate.
Elsewhere, Villarreal beat Zenit St Petersburg 2-1 to complete a 5-2 aggregate win, Benfica overturned a 1-0 deficit from the first leg to beat Dinamo Zagreb 3-1 overall and Valencia secured a 1-1 draw at Krasnador to progress 3-2.
Imperious Barcelona thumped visitors Borussia Dortmund 4-0 in their Champions League quarter-final first leg on Wednesday after Robert Lewandowski netted twice against his old club to earn the Catalans a sizeable lead.
Paris Saint-Germain were made to sweat to secure a 3-1 win over Aston Villa in the first leg of their Champions League quarter-final, coming from behind after a shock opener from the visitors on Wednesday.
His Highness Sheikh Hamdan bin Mohammed bin Rashid Al Maktoum, Crown Prince of Dubai and the UAE's Deputy Prime Minister and Defence Minister, met with Jay Shah, Chairman of the International Cricket Council (ICC), in Mumbai on Wednesday.
Jannik Sinner will return to the ATP Tour from his doping ban at next month's Rome Masters as world number one after the Italian's closest challenger Alexander Zverev crashed to an early defeat in Monte Carlo on Tuesday.
Inter Milan's Davide Frattesi overcame personal heartbreak to net a late winner in Tuesday's 2-1 Champions League win at Bayern Munich on Tuesday after the midfielder's grandmother died the day before the first leg of their quarter-final tie.
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