Hamas leader Ismail Haniyeh was killed in Iran's Tehran, the Palestinian group Hamas said in a statement on Wednesday.
In a statement, Hamas mourned the death of Haniyeh, who it said was killed in a "raid on his residence in Tehran".
According to the Islamic Revolutionary Guard, Haniyeh and one of his bodyguards were killed after the building they were staying in was struck early Wednesday. The statement said a probe is underway to find the cause of the incident.
Haniyeh was in Tehran to attend the inauguration ceremony of Iran’s President Masoud Pezeshkian, on Tuesday.
There was no immediate comment from Israeli authorities.
The White House did not immediately respond to a request for comment on Haniyeh.
The news, which came less than 24 hours after Israel claimed to have killed the Hezbollah commander it said was behind a deadly strike in the Israeli-occupied Golan Heights, appears to set back chances of any imminent ceasefire agreement in Gaza.
"This assassination by the Israeli occupation of Brother Haniyeh is a grave escalation that aims to break the will of Hamas," senior Hamas official Sami Abu Zuhri told Reuters.
He said Hamas would continue the path it was following, adding: "We are confident of victory."
Haniyeh, normally based in Qatar, has been the face of the Palestinian group's international diplomacy as the war set off by the Hamas-led attack on Israel on October 7 has raged in Gaza, where three of his sons were killed in an Israeli airstrike.
Appointed to the Hamas top job in 2017, Haniyeh has moved between Turkey and Qatar's capital Doha, escaping the travel curbs of the blockaded Gaza Strip and enabling him to act as a negotiator in ceasefire talks or to talk to Hamas' ally Iran.